#1

\documentclass[b4j]{tetsujsarticle}
\usepackage{tetsuchem}

\def\title#1{\br2\小見出し{#1}\br{.5}}
\begin{document}
\nousece
\setcrambond{2pt}{}{}
\setatomsep{2em}

\title{サリチル酸の二量体}

\chemfig{%
  [:30]*6(-(-OH)=(-C(=[1]O%
  -[,,,,dash pattern=on 1pt off 0.8pt]HO-[7]C(-(*6(=-=-=(-HO)-)))
    (=[5]O-[4,,,,dash pattern=on 1pt off 0.8pt]\phantom{H})
  )(-[7]OH))-=-=)
}

\title{フグ毒の成分 テトロドトキシン}

\setatomsep{3em}

\newlength{\bond}
\newlength{\bondw}
\setlength{\bond}{1.5pt}
\setlength{\bondw}{3\bond}
\def\bgcolor{white}

\setcrambond{\bond}{}{}
\chemfig{%
  ?[a]
  (-[:60]-[0]OH)
  (-[6]OH)
  -[:170]?[b]-[:230]?[c]-[:10]
  %
  (<[:230]\chembelow{N}{H}-[:170,,,,line width=\bond]
    (=[:230]HN)
    >[:190]HN-[:50]?[c]
    (-[:190]HO))
  %
  (-[:-10,,,,\bgcolor,line width=\bondw])-[:-10]
  (<[:5]OH)-[:50]?[a]
  (-[2,,,,\bgcolor,line width=\bondw]\phantom{O})
  (-[2]O-[:170]
    (-[2]OH)
    (-[:190]O?[b])
    (<[:230]
      (-[:170,,,,\bgcolor,line width=\bondw])
      (-[:170]HO)
      (-[6,,,,\bgcolor,line width=\bondw])
      (-[6,,,,line width=\bond])
      (>[:50])%redraw
  ))}

\title{シアノコバラミン（ビタミンB12）}

\setatomsep{2.5em}

\chemfig{Co\rlap{${}^+$}(?[f])(-[2]CN)
  %
  (-[7,,,,<-]N*5(=(?[d])-(<:-[::60]-[::-60](=[::-60]O)-[::60]NH_2)
  -(<[::-39]CH_3)(<:[::-69]CH_3)-?[a]-))
  %
  (-[1,,,,<-]N*5(=(-[,0.6]?[a,{=}])
  -(<:-[::-60]-[::60](=[::60]O)-[::-60]NH_2)
  -(<[::-84]-[::60](=[::60]O)
  -[::-60]NH_2)(<:[::-24]CH_3)-?[b]-))
  %
  (-[3,,,,<-]N*5(=(-[,0.6]?[b,{=}](-[::60]CH_3))
  -(<:-[::-60]-[::60](-[::60]H_2N)=[::-60]O)
  -(<[::-84]-[::-60](-[::60]H_2N)=[::-60]O)(<:[::-24]H_3C)
  -?[c](<:[::-90]H_3C)
  -))
  %
  -[5]N*5(-(?[c])(<[::0]H)
  -(<-[::-60](-[::60]H_2N)=[::-60]O)
  -(<[::-24]CH_3)
  (<:[::-84]
  -[::60]-[::-60](=[::-60]O)-[::60]NH-[::-60]-[::60]
  (<:[::60,0.7]CH_3)-[::-60]O
  -[::60]P(=[::90]O)(-[::-90]HO)-[::0]O
  -[6]*5([::36]-(-[6]-[::-60]HO)<O>
  (-[2,4.7]N*5([::-18]-(*6(=-(-CH_3)=(-CH_3)-=-))
  --N(?[f,,{dash pattern=on 1pt off 0.8pt}]\phantom{N})=-))
  -(-[2,,,2]HO)-))
  %
  -(=[,0.6](?[d])-[::-60]CH_3)-)}


\title{イベルメクチン（ノーベル医学生理学賞2015）}

\setatomsep{1.75em}
\chemfig{H -[2]?[a](-[2,,,2]HO) <[7](-[2,0.5]H)(-[6]OCH_3)-[,1.2,,,line width=2pt]>[1](-[6]H)(-[3] O -[4,1.2]?[a](-[2]H)(-[6,0.4]CH_3)) -[2,1.3] O -[2] ?[b](-[2,,,2]HO) <[7](-[2,0.5]CH_3)(-[6]H)-[,1.2,,,line width=2pt]O>[1](-[2]H)(-[3] -[4,1.2]?[b](-[6,0.4]H)(-[2]OCH_3)) -[6] O>:[7]?[c](<[2]H) -[6,1.3] (<[6]H)(<:[5,,,2]H_3C) -[:-30,1.2]=[6]-[:-30,1.2]=[6]([:-72]*5(--O-(<:[6,0.9]H)(*6(-(<[:-60,0.9]OH)(<:[:-120,0.9]H)-(-CH_3)=-(-[2,1.2](=[:150]O)-[:30]O -[2] (<:[:-30]H) *6(--
(<[:-30]-[:30]-[2]?[d](<[7]CH_3)(<:[1]H))(<:[2]O-[:30]?[d](<[1]H)-[2,1.2](<:[1]CH_3)(<[2]H)-[:150]-[:-150,,,2]H_3C)
-O-(-[,1.1]-[:-150,1.2]=[:150,1.2]?[c]-[2]CH_3)--))(<[:30]H)-))--))}


\end{document}